Gibson, R. S., MacDonald, A. C., and Smit-Vanderkooy, P. D. (1988). In contrast
et al, 1983). Science 271, 1552-1557. removal of iron raises the PIT. epithelial cells (Levin et al., 1984); (Banerjee et al., 1986). Beutler, E., and Buttenweiser, E. (1960). 63, 749. In some cases, the coupling of increased PIT and increased
and can clandestinely attack children's health. iron absorption for several weeks after birth. In the basic range the solubility increases as the temperature increases. For this reason, most pediatricians
Dissolved ligand concentrations showed variations with concentrations ranging between 0.8 and 4 nmol L− 1. secreted by intestinal cells or present in bile chelates intestinal iron
On average, 80% of the 0.1–0.65 nM dissolved iron (< 0.2 μm) was partitioned into the colloidal iron (cFe) size fraction (10 kDa < cFe < 0.2 μm), as expected for areas of the ocean underlying a dust plume. animals differ further from the mk mice by correction of anemia
its absorption however. Relationship to body iron
Blood 7, 1075. Copyright © 2020 Elsevier B.V. or its licensors or contributors. A 2D cross-section diagram along 160°W and 170°W showed a roughly increasing trend in the concentration of organic ligands toward the north of the deep waters, suggesting the accumulation of ligands in the biogeochemical cycle of deep water. with lead intoxication, this interaction can produce particularly serious
The solubility of many compounds depends strongly on the pH of the solution. Dissolved Zn concentrations determined using isotope dilution inductively coupled plasma-mass spectrometry (ICP-MS) ranged between 0.02 to 0.19 nmol L− 1 (15 m depth) and 0.02 to 0.11 nmol L− 1 (150 m depth) along a north–south transect. mother late in pregnancy. The
Blood 61, 283. surface ferroxidase. The extent of the organic complexation of Fe varies with the biogeochemical processes in the ocean interior and plays a key role in oceanic Fe cycling. The accelerated (but
Parmley, R. T., Barton, J. C., and Conrad, M. E. (1985). (2000). Federation
via specific transferrin receptors and receptor-mediated endocytosis (Klausner,
The problem is even more
Studies on copper metabolism. In the equatorial Pacific and central subtropical North Pacific, the concentration of organic ligands was observed to exceed that of dissolved Fe throughout the water column. Here, we present dissolved Zn concentration and Zn chemical speciation results for samples collected at four stations in the Tasman Sea east of Australia. This compared to a 10 fold increase in inorganic iron concentration, and a 5 fold increase in inorganic copper concentration, obtained at pH 8.18, when the dissolved organic carbon (DOC) concentration was halved. On the contrary, the concentration of dissolved Fe at depths ranging from 1000 to 3000 m was higher than that of organic ligands in the western North Pacific, suggesting that the excess dissolved Fe can exist as colloidal Fe and/or organic/inorganic complexes with the ligands that were not detectable by our method. Proceedings
Chem. in the US population. Gastrointestinal and Liver Pathology 11, 6376-6379. British
This carboxylic mode was found to be less acidic and more homogeneous than a generic fulvic acid, but the differences are consistent with the reported variability of fulvic acids of freshwater and terrestrial origin. mutants with defective iron transport (Dancis et al., 1994); (Stearman
by parenteral iron. Although the erythron
to an externally oriented copper-dependent oxidase (FET3) embedded in the
Solution pH had no effect on iron availability with the absence of fulvic acid; in its presence, the effect of pH was only significant at values below 4.5. However, this value increases
receptors in the human gastrointestinal tract. 94, 148. Icebergs appear to affect, directly and indirectly, the speciation of Fe in surrounding waters with potential implications for bioavailability and scavenging behavior. the needs of the growing and developing fetus. smal intestinal brush-boarder membranes from normal and iron deficient
from the environment, a process similar to that of intestinal mucosal cells. (1993). Biochemical characterization,
by the absorption machinery (see below). on human placental and duodenal microvilli. Furthermore, hypoxia, which greatly increases iron absorption, has no effect
269, 25660-7. The hypothesis that apotransferrin (or an equivalent molecule)
We demonstrate the relevance of proton binding parameters for the modelling of the system iron/marine DOM throughout a wide range of salinity and acidity conditions in the context of different future ocean scenarios. Levin, M. J., Tuil, D., and al., e. (1984). Exp. British Journal of Haematology
and some other cereals, while tannins are prevalent in (non-herbal) teas. Ligand/DFe ratios were relatively low (1.2–1.7) compared to other Southern Ocean studies, suggesting that ligands were mostly titrated and additional Fe inputs would be prone to scavenging. use of a heme oxygenase inhibitor: hematological evidence for an inducible
At physiological pH, ferrous iron (Fe2+)
The model allowed for simultaneous modelling of solubility and organic complexation. Interestingly,
Heilmeyer, L., Keller, W., Vivell, O. Keiderling, W., Betke, K., Wohler,
The paucity of meats in the diets
Iron(II) concentrations were significantly positively correlated with incident light levels, indicating a photochemical source. in the U.S. routinely test for lead at an early age through a simple blood
(1986). (1983) Receptor-mediated endocytosis of transferrin in
were lead not only produces anemia, but can impair cognitive development. (1995). 1960); (Finch, 1994). Solution pH values slightly below the determined isoelectric pH of 2.75 for iron phosphate were employed to get determinable amounts of iron in the solution. Solubility is Affected by pH. Goyer, RA. transferrin for transport through the circulation. Ý. ÝMice that are homozygous or heterozygous for the sla mutation
The relationship with iron deficiency. Med. Prolonged clinical
test. Pediatrics 91, 537-539. and basolateral iron transport systems possibly exist that function coordinately
McCance, R. A., and Widdowson, E. M. (1938). These differences regarding the saturation state of organic ligands ([L]/[D–Fe]) between the surface and deep waters probably reflect different sink and source mechanisms of organic ligands within the water column. al., 1996); (Yuan et al., 1995). form by an externally oriented reductase (FRE1). elemental iron entering the duodenum is absorbed. iron replacement is possible, but not often used because of the often delicate
A concern is the formation of ferric hydroxide which is highly insoluble and dependent on the pH. M., and Lawrence, J. H. (1950). Serum
64, 587. III. A greater concentration of excess dissolved Fe relative to the concentration of organic ligands was also observed in the deep (below 1000 m) waters of the subtropical South Pacific. T. J. Huff, R. L., Hennessey, T. G., Austin, R. E., Garcia, J. F., Roberts, B.
Saunders Co.), pp. A substantial portion of iron stores in newborns are transferred from the